[NCEZID] Laboratory Response Network

OMB Control No: 0920-0850	ICR Reference No: 202602-0920-006
Status: Active	Previous ICR Reference No: 202210-0920-015
Agency/Subagency: HHS/CDC	Agency Tracking No: 0920-0850
Title: [NCEZID] Laboratory Response Network
Type of Information Collection: Revision of a currently approved collection	Common Form ICR:  No
Type of Review Request: Regular
OIRA Conclusion Action: Approved without change	Conclusion Date: 04/02/2026
Retrieve Notice of Action (NOA)	Date Received in OIRA: 02/12/2026
Terms of Clearance:

	Inventory as of this Action	Requested	Previously Approved
Expiration Date	04/30/2029	36 Months From Approved	04/30/2026
Responses	90,690	0	85,253
Time Burden (Hours)	59,024	0	422,716
Cost Burden (Dollars)	0	0	0

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Abstract: The Laboratory Response Network is an integrated national and international network of laboratories that can respond to suspected acts of biological, chemical, or radiological terrorism and other public health emergencies. Member laboratories submit information regarding the testing capabilities of the laboratory; report all biological and chemical testing results; and participate in Proficiency Testing Challenges or Validation. The goal of the study is to identify gaps in preparedness for biological threats and emerging infectious diseases. The data will be used to develop strategies, policies, and operating procedures for responding to biological threat emergencies. The LRN website, Results Messenger data exchange application, and Special Data Calls Questionnaires are methods used to collect data from member laboratories. There is a reduction in Burden Hours from the previously approved collection due to a decrease in participating laboratories. In this revision, the burden has been reduced by the continued expansion of LRN laboratories implementing HL7 reporting and decreasing the need for manual entry to Results Messenger. The number of data elements collected for the LRN Data Exchange has also been reduced. Numerical test results (i.e. Ct values) or a sample conclusion are no longer collected. As part of laboratory qualification data collection, the ability to add program feedback was added. Burden was further reduced by re-evaluating the burden calculation based upon requirements LRN places upon the member laboratories versus the requirements of the Clinical Laboratory Improvement Amendments (CLIA) regulations and other quality management programs place upon the laboratories. In the instance of proficiency tests and challenge panels, the analysis of these samples is required by CLIA and/or other quality management systems implemented locally.

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Authorizing Statute(s): US Code: 42 USC 241 Name of Law: Public Health Service Act    EO: EO 39 Name/Subject of EO: Presidential Decision Directive 39

Citations for New Statutory Requirements: None

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Associated Rulemaking Information
RIN:	Stage of Rulemaking:	Federal Register Citation:	Date:
	Not associated with rulemaking

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Federal Register Notices & Comments
60-day Notice:	Federal Register Citation:	Citation Date:
	90 FR 38652	08/11/2025
30-day Notice:	Federal Register Citation:	Citation Date:
	91 FR 6222	02/11/2026
Did the Agency receive public comments on this ICR? Yes

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Number of Information Collection (IC) in this ICR: 6

IC Title Form No. Form Name Biological Threat Surge Event Testing Results 0920-0850 Biological Threat Surge Event Challenge Panel and Validation Testing Results 0920-0850 Challenge Panel and Validation Chemical Threat Surge Event and Exercise Testing Results 0920-0850 Chem Threat Surge and Exercise Laboratory Qualification 0920-0850 Laboratory Qualification Data Proficiency and Validation Testing Results 0920-0850 Proficiency and Validation Routine Testing Results 0920-0850 Routine Testing Data Elements Surge Event Testing Results/Exercises 0920-0850 Surge Event Testing Results/Exercises

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ICR Summary of Burden

	Total Approved	Previously Approved	Change Due to New Statute	Change Due to Agency Discretion	Change Due to Adjustment in Estimate	Change Due to Potential Violation of the PRA
Annual Number of Responses	90,690	85,253	0	5,608	-171	0
Annual Time Burden (Hours)	59,024	422,716	0	-351,380	-12,312	0
Annual Cost Burden (Dollars)	0	0	0	0	0	0

Burden increases because of Program Change due to Agency Discretion: Yes

Burden Increase Due to: Miscellaneous Actions

Burden decreases because of Program Change due to Agency Discretion: Yes

Burden Reduction Due to: Miscellaneous Actions

Short Statement: This is a revision of a previous collection seeking approval of 59,024 annual burden hours and 3 years of approval.

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Annual Cost to Federal Government: $3,001,147

Does this IC contain surveys, censuses, or employ statistical methods? No

Does this ICR request any personally identifiable information (see OMB Circular No. A-130 for an explanation of this term)? Please consult with your agency's privacy program when making this determination.     Yes

Does this ICR include a form that requires a Privacy Act Statement (see 5 U.S.C. §552a(e)(3))? Please consult with your agency's privacy program when making this determination.     No

Is this ICR related to the Affordable Care Act [Pub. L. 111-148 & 111-152]? No

Is this ICR related to the Dodd-Frank Wall Street Reform and Consumer Protection Act, [Pub. L. 111-203]? No

Is this ICR related to the American Recovery and Reinvestment Act of 2009 (ARRA)? No

Is this ICR related to the Pandemic Response? No

Agency Contact: Odion Clunis 770 488-0045 [email protected]

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Common Form ICR:  No

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On behalf of this Federal agency, I certify that the collection of information encompassed by this request complies with 5 CFR 1320.9 and the related provisions of 5 CFR 1320.8(b)(3).
The following is a summary of the topics, regarding the proposed collection of information, that the certification covers:
		(a) It is necessary for the proper performance of agency functions;
		(b) It avoids unnecessary duplication;
		(c) It reduces burden on small entities;
		(d) It uses plain, coherent, and unambiguous language that is understandable to respondents;
		(e) Its implementation will be consistent and compatible with current reporting and recordkeeping practices;
		(f) It indicates the retention periods for recordkeeping requirements;
		(g) It informs respondents of the information called for under 5 CFR 1320.8 (b)(3) about:
			(i) Why the information is being collected;
			(ii) Use of information;
			(iii) Burden estimate;
			(iv) Nature of response (voluntary, required for a benefit, or mandatory);
			(v) Nature and extent of confidentiality; and
			(vi) Need to display currently valid OMB control number;
		(h) It was developed by an office that has planned and allocated resources for the efficient and effective management and use of the information to be collected.
		(i) It uses effective and efficient statistical survey methodology (if applicable); and
		(j) It makes appropriate use of information technology.
If you are unable to certify compliance with any of these provisions, identify the item by leaving the box unchecked and explain the reason in the Supporting Statement.
Certification Date: 02/12/2026

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